{"product_id":"recombinant-histone-h4-mono-methyl-lys12-monoclonal-antibody","title":"Recombinant Histone H4 (Mono Methyl Lys12) Monoclonal Antibody","description":"\u003cp\u003e\u003cb\u003eSize:\u003c\/b\u003e:50μL\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e:Store at -20℃ Valid for 12 months. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e:Ice bag\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e:12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e:Primary Antibodies\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e:Monoclonal Antibodies;Recombinant Antibodies;Acetyl\/Phospho\/Methyl Antibodies\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e:Histone H4 (Mono Methyl Lys12)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e:H4F;methyl histone H;methylated histone H;HIST2H;HIST1H;HISTH4H;histone H;HIST2H4B;H4\/o;histone H4;HIST1H4A;FO108;H4\/p;HIST1H4;Hist4h4;HISTH4H4;methyl histone H4;methylated histone H4;H4\/A;H4FA;H4\/I;H4FI;HIST1H4B;H4\/G;H4FG;HIST1H4C;H4\/B;H4FB;HIST1H4D;H4\/J;H4FJ;HIST1H4E;H4\/C;H4FC;HIST1H4F;H4\/H;H4FH;HIST1H4H;H4\/M;H4FM;HIST1H4I;H4\/E;H4FE;H4\/D;H4FD;HIST1H4K;H4\/K;H4FK;HIST1H4L;H4\/N;H4F2;H4FN;HIST2H4;HIST2H4A;H4;H4C1;H4C2;H4C3;H4C4;H4C5;H4C6;H4C8;H4C9;H4C11;H4C12;H4C13;H4C14;H4C15;H4-16;A;I;H4B;H4J;H4H;H4M;H4E;HIST1H4J;H4D;H4C;H4\/p;histone H4;HIST1H4B H4\/I\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Epigenetics and Nuclear Signaling\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e:Unconjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eHost\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies reactivity\u003c\/b\u003e:Human;Rat;Mouse\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e:WB;IHC;IF;FCM;IP;ChIP\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG,κ\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Monoclonal;Recombinant\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone NO.\u003c\/b\u003e:A838\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e:P62805\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:The amino-terminal tails of core histones undergo lysine methylation in multiple sites, termed as “histone code” or “epigenetic code”. Lysine methylation in core histones is a major determinant for the formation of active and inactive regions of the genome and therefore plays vital roles in multiple cellular events. In most species, lysine methylation occurs primarily on histones H3 (Lys4, 9, 27, 36, 79) and H4 (Lys5, 8, 12, 20) and has been implicated in both transcriptional activation and silencing. Methylation in histones modulated by specific histone methyltransferases (HMTs) and histone demethylases (HDMs) is impaired in the pathologies of cancer and other diseases and therefore, enzymes regulating histone lysine methylation have become promising targets for anti-cancer drugs.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e:1 mg\/mL\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Monomethylated human histone H4 (Lys12) peptide\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification method\u003c\/b\u003e:Protein A purified\u003c\/p\u003e\u003cp\u003e\u003cb\u003eDilution\u003c\/b\u003e:WB 1:500-1:2000;IHC 1:100-1:500;IF 1:50-1:200;FCM 1:50;ChIP 6 μg\/5×10\u003csup\u003e6\u003c\/sup\u003e cells;IP 1:25-1:50\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e:11 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e:11 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":48644796448868,"sku":"AN302114L","price":349.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_c1b1ab95-f9fe-48b3-8c11-44909ee72faa.jpg?v=1782654716","url":"https:\/\/www.genebiosystems.com\/en-fr\/products\/recombinant-histone-h4-mono-methyl-lys12-monoclonal-antibody","provider":"GeneBio ","version":"1.0","type":"link"}