{"product_id":"p62-sqstm1-polyclonal-antibody","title":"P62\/SQSTM1 Polyclonal Antibody","description":"\u003cp\u003e\u003cb\u003eSize:\u003c\/b\u003e:120μL\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e:Store at -20℃ Valid for 12 months. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e:12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e:Primary Antibodies\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e:Polyclonal Antibodies\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e:P62\/SQSTM1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e:A170;DMRV;EBI 3 associated protein of 60 kDa;EBI 3 associated protein p60;EBI3 associated protein of 60 kDa;EBI3 associated protein p60;EBI3-associated protein of 60 kDa;EBIAP;FTDALS3;MGC127197;ORCA;OSF-6;Osi;OSIL;Oxidative stress induced like;p60;p62;p62B;Paget disease of bone 3;PDB 3;PDB3;Phosphotyrosine independent ligand for the Lck SH2 domain of 62 kDa;Phosphotyrosine independent ligand for the Lck SH2 domain p62;Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa;PKC-zeta-interacting protein;Protein kinase C-zeta-interacting protein;Sequestosome 1;Sequestosome-1;SQSTM 1;SQSTM;Sqstm1;STAP;STONE14;Ubiquitin binding protein p62;Ubiquitin-binding protein p62;ZIP 3;ZIP;ZIP3\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Cancer;Cardiovascular;Epigenetics and Nuclear Signaling;Metabolism;Signal Transduction\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e:Unconjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eHost\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies reactivity\u003c\/b\u003e:Human;Mouse;Rat\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e:WB\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone NO.\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e:Q13501,Q64337,O08623\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Sequestosome 1 (SQSTM1\/p62) is a multifunctional adaptor protein implicated in selective autophagy,cell signaling pathways,and tumorigenesis. p62 has been implicated in shuttling ubiquitinated and sometimes aggregated proteins for autophagic degradation. As a autophagy-specific substrate,p62 is degraded during the autophagic process,which makes intracellular level of p62 as a marker for autophagy flux. p62 is at the cross-roads of several signaling pathways including Ras\/ Raf\/ MAPK and NFκB and plays important role in cancer. p62 is a component of inclusion bodies\/ protein aggregates found in human diseases,including Huntington's disease,Alzheimer's disease,Parkinson's disease in the brain,and nephropathic cystinosis in kidney (22074114,22860231,22714671). The molecular weight of p62 is predicted as 48\/ 38 kDa,while western blot analyses using this antibody demonstrate the major band around 60-62 kDa in various tissues.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e:1.5 mg\/mL\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:KLH conjugated Synthetic peptide corresponding to Human SQSTM1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification method\u003c\/b\u003e:Affinity purification\u003c\/p\u003e\u003cp\u003e\u003cb\u003eDilution\u003c\/b\u003e:WB 1:500-1:2000\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e:48kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e:62kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":48644659249252,"sku":"E-AB-70387","price":364.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_1d983b56-1d5a-4828-83ac-f35d9f588bb0.jpg?v=1782650457","url":"https:\/\/www.genebiosystems.com\/en-fr\/products\/p62-sqstm1-polyclonal-antibody","provider":"GeneBio ","version":"1.0","type":"link"}