{"product_id":"oas1-antibody-biotin-conjugated-cat-csb-pa640913ld01hu","title":"OAS1 Antibody, Biotin conjugated - Cat. #: CSB-PA640913LD01HU","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:50ug\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:(2 5')oligo(A) synthetase 1 antibody; (2-5'')oligo(A) synthase 1 antibody; 2 5 Oligoadenylate Synthetase 1 antibody; 2 5' oligo A synthase 1 antibody; 2 5' oligo A synthetase 1 antibody; 2 5A synthase 1 antibody; 2 5A synthetase 1 antibody; 2' 5' oligo A synthetase 1 antibody; 2' 5' oligoadenylate synthetase 1 40\/46kDa antibody; 2' 5' oligoadenylate synthetase 1 antibody; 2' 5' oligoisoadenylate synthetase 1 antibody; 2''-5''-oligoadenylate synthase 1 antibody; 2'5' oligo A synthetase 1 antibody; 2'5' oligoadenylate synthetase 1 antibody; 2'5' oligoisoadenylate synthetase 1 antibody; 2-5A synthase 1 antibody; E18\/E16 antibody; IFI 4 antibody; IFI4 antibody; OAS 1 antibody; OAS1 antibody; OAS1_HUMAN antibody; OIAS antibody; OIASI antibody; p46\/p42 OAS antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:P00973\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Recombinant Human 2\\'-5\\'-oligoadenylate synthase 1 protein (296-395AA)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2\\'-5\\'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:\u0026gt;95%, Protein G purified\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Biotin\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Preservative: 0.03% Proclin 300\u003cbr\u003eConstituents: 50% Glycerol, 0.01M PBS, pH 7.4\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:Liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:OAS1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Epigenetics and Nuclear Signaling\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40486883164260,"sku":"CSB-PA640913LD01HU","price":331.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_ae255e0f-a95a-4715-8e10-508c8263da46.jpg?v=1660155248","url":"https:\/\/www.genebiosystems.com\/en-fr\/products\/oas1-antibody-biotin-conjugated-cat-csb-pa640913ld01hu","provider":"GeneBio ","version":"1.0","type":"link"}