NOTCH3 Antibody - Cat. #: CSB-PA586591

SKU: CSB-PA586591

Size :50ul

Clone Number:

Aliases:CADASIL antibody; CASIL antibody; NOTC3_HUMAN antibody; Notch 3 antibody; Notch 3 intracellular domain antibody; Notch homolog 3 antibody; Notch3 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9UM47

Immunogen:Synthetic peptide of Human NOTCH3

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB, IHC; ELISA:1:1000-1:5000, WB:1:200-1:1000, IHC:1:25-1:100

Background:This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:NOTCH3

Research Areas:Epigenetics and Nuclear Signaling?Neuroscience;Cardiovascular;Stem cells