{"product_id":"mapkap1-antibody-cat-csb-pa857767esr2hu","title":"MAPKAP1 Antibody - Cat. #: CSB-PA857767ESR2HU","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:50ul\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:MAPKAP 1 antibody; MAPKAP1 antibody; MEKK2 interacting protein 1 antibody; MGC2745 antibody; MIP 1 antibody; MIP1 antibody; Mitogen activated protein kinase associated protein 1 antibody; Mitogen-activated protein kinase 2-associated protein 1 antibody; mSIN1 antibody; OTTHUMP00000064207 antibody; Ras inhibitor MGC2745 antibody; SAPK interacting protein 1 antibody; SAPK-interacting protein 1 antibody; SIN 1 antibody; SIN1_HUMAN antibody; SIN1b antibody; SIN1g antibody; Stress activated map kinase interacting protein 1 antibody; Stress activated protein kinase interacting 1 antibody; Stress-activated map kinase-interacting protein 1 antibody; Target of rapamycin complex 2 subunit MAPKAP1 antibody; TORC2 subunit MAPKAP1 antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:Q9BPZ7\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Recombinant Human Target of rapamycin complex 2 subunit MAPKAP1 protein (1-290AA)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, WB; Recommended dilution: WB:1:500-1:2000\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 \\\\\\'Ser-473\\\\\\' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on \\\\\\'Thr-308\\\\\\' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at \\\\\\'Ser-422\\\\\\'. mTORC2 also modulates the phosphorylation of PRKCA on \\\\\\'Ser-657\\\\\\'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:Antigen Affinity Purified\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:Liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:MAPKAP1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Signal transduction\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40486026870884,"sku":"CSB-PA857767ESR2HU","price":331.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_02ff49bd-d2d6-421b-9456-b3a7b101e49a.jpg?v=1660139733","url":"https:\/\/www.genebiosystems.com\/en-fr\/products\/mapkap1-antibody-cat-csb-pa857767esr2hu","provider":"GeneBio ","version":"1.0","type":"link"}