{"product_id":"kdm4a-antibody-fitc-conjugated-cat-csb-pa012137lc01hu","title":"KDM4A Antibody, FITC conjugated - Cat. #: CSB-PA012137LC01HU","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:50ug\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:JHDM3A antibody; JmjC domain containing histone demethylation protein 3A antibody; JmjC domain-containing histone demethylation protein 3A antibody; JMJD2 antibody; JMJD2A antibody; jumonji C domain containing histone demethylase 3A  antibody; Jumonji domain containing 2 antibody; Jumonji domain containing 2A antibody; Jumonji domain containing protein 2A antibody; Jumonji domain-containing protein 2A antibody; KDM4A antibody; KDM4A_HUMAN antibody; KIAA0677 antibody; Lysine (K) specific demethylase 4A antibody; Lysine-specific demethylase 4A antibody; TDRD14A antibody; Tudor domain containing 14A antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:O75164\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Recombinant Human Lysine-specific demethylase 4A protein (127-364AA)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Histone demethylase that specifically demethylates \\'Lys-9\\' and \\'Lys-36\\' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 \\'Lys-4\\', H3 \\'Lys-27\\' nor H4 \\'Lys-20\\'. Demethylates trimethylated H3 \\'Lys-9\\' and H3 \\'Lys-36\\' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:\u0026gt;95%, Protein G purified\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:FITC\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Preservative: 0.03% Proclin 300\u003cbr\u003eConstituents: 50% Glycerol, 0.01M PBS, PH 7.4\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:Liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:KDM4A\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Epigenetics and Nuclear Signaling\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40486295535716,"sku":"CSB-PA012137LC01HU","price":333.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_8c150f27-3979-4c1d-9a85-3bc54638e74a.jpg?v=1660144359","url":"https:\/\/www.genebiosystems.com\/en-fr\/products\/kdm4a-antibody-fitc-conjugated-cat-csb-pa012137lc01hu","provider":"GeneBio ","version":"1.0","type":"link"}