{"product_id":"invivomab-anti-mouse-cd279-pdcd1-pd1-antibody-rmp1-14","title":"InVivoMAb Anti-Mouse CD279\/PDCD1\/PD1 Antibody (RMP1-14)","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e:100ug\u003c\/p\u003e\u003cp\u003e\u003cb\u003eDescription\u003c\/b\u003e:The RMP1-14 monoclonal antibody recognizes mouse PD-1 (CD279), a 50–55 kDa CD28-family receptor transiently expressed on thymocytes, activated T and B cells, and myeloid cells. PD-1 contains an ITIM motif and delivers inhibitory signals upon engagement with its ligands PD-L1 and PD-L2, reducing T-cell activation and promoting peripheral tolerance. PD-1 deficiency in mice leads to autoimmunity, while PD-L1 upregulation in tumors enhances resistance to CD8 T-cell–mediated killing. Blocking the PD-1\/PD-L1 pathway can inhibit tumor growth in mouse models. RMP1-14, like J43, effectively blocks PD-1 binding to both PD-L1 and PD-L2.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eHost species\u003c\/b\u003e:Mouse\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies reactivity\u003c\/b\u003e:Mouse\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:Liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage buffer\u003c\/b\u003e:0.01M PBS, pH 7.4.\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:\u0026gt;95% as determined by SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Monoclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG2a, kappa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplications\u003c\/b\u003e:in vivo blocking of PD-1\/PD-L signaling\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget\u003c\/b\u003e:Programmed cell death protein 1, Protein PD-1, mPD-1, CD279, Pdcd1, Pd1\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification\u003c\/b\u003e:Protein A\/G purified from cell culture supernatant.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin level\u003c\/b\u003e:Please contact us for this information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e:Q02242\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStability and Storage\u003c\/b\u003e:Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone ID\u003c\/b\u003e:RMP1-14\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Usage Information\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePredicted molecular weight\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eNote\u003c\/b\u003e:For research use only. Not suitable for clinical or therapeutic use.\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":48672690798692,"sku":"MS870030","price":529.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_2670cbcc-039d-4343-8cac-2d61cca82f09.jpg?v=1782933745","url":"https:\/\/www.genebiosystems.com\/en-fr\/products\/invivomab-anti-mouse-cd279-pdcd1-pd1-antibody-rmp1-14","provider":"GeneBio ","version":"1.0","type":"link"}