{"product_id":"human-kelch-like-ech-associated-protein-1-keap1-elisa-kit","title":"Human Kelch-like Ech-associated Protein 1, KEAP1 ELISA Kit","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e:96 Tests-1 Kit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2\/NRF2 for ubiquitination (PubMed: 1$458.00|$300.005973, PubMed: 15379550, PubMed: 15572695, PubMed: 15983046, PubMed: 15601839). KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2\/NRF2, a transcription factor regulating expression of many cytoprotective genes (PubMed: 15601839, PubMed: 16006525). In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2\/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes (PubMed: 19489739, PubMed: 16006525, PubMed: 17127771, PubMed: 18251510, PubMed: 29590092). In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1\/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2\/NRF2 (PubMed: 20452972). The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1\/p62, increasing SQSTM1\/p62 sequestering activity and degradation (PubMed: 28380357). The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome (PubMed: 15379550, PubMed: 17046835).\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch_area\u003c\/b\u003e:Epigenetics and Nuclear Signaling\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplications\u003c\/b\u003e:ELISA\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget_protein\u003c\/b\u003e:KEAP1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReactivity\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAssay type\u003c\/b\u003e:Sandwich\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSensitivity\u003c\/b\u003e:7.87ng\/L\u003c\/p\u003e\u003cp\u003e\u003cb\u003eDetection range\u003c\/b\u003e:15-3000ng\/L\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSample type\u003c\/b\u003e:Serum, plasma or other biological fluids\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFull product name\u003c\/b\u003e:Kelch-Like Ech-Associated Protein 1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e:2-8ºC\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAssay time\u003c\/b\u003e:1h 30m\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt accession\u003c\/b\u003e:Q14145\u003c\/p\u003e\u003cp\u003e\u003cb\u003eMASS(Da)\u003c\/b\u003e:69,666\u003c\/p\u003e\u003cp\u003e\u003cb\u003eGeneID\u003c\/b\u003e:9817\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSynonyms\u003c\/b\u003e:Cytosolic inhibitor of Nrf2;INrf2;KEAP 1;KEAP1;Kelch-like ECH-associated protein 1;Kelch-like protein 19\u003c\/p\u003e\u003cp\u003e\u003cb\u003eGene names\u003c\/b\u003e:KEAP1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStandard solution\u003c\/b\u003e:3200ng\/L\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":40500593688676,"sku":"E5534Hu","price":703.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_83222101-5711-47d5-989b-d653f58c3856.jpg?v=1660526759","url":"https:\/\/www.genebiosystems.com\/en-fr\/products\/human-kelch-like-ech-associated-protein-1-keap1-elisa-kit","provider":"GeneBio ","version":"1.0","type":"link"}