{"product_id":"hbegf-polyclonal-antibody-ab","title":"HBEGF Polyclonal Antibody","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e:100μL\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptors with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.,PTM:O-linked glycan attachment sites were determined by Edman degradation, O-glycanase digest suggests mucin-type glycosylation (done in HB-EGF purified from histiocytic lymphoma cell line U-937).,PTM:Several N-termini have been identified by direct sequencing. The forms with N-termini 63, 73 and 74 have been tested and found to be biologically active.,Contains 1 EGF-like domain.,subcellular location:Mature HB-EGF is released into the extracellular space and probably binds to a receptor.,\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch_area\u003c\/b\u003e:Cancer; Cardiovascular; Signal transduction\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget_protein\u003c\/b\u003e:HBEGF\u003c\/p\u003e\u003cp\u003e\u003cb\u003eapplications\u003c\/b\u003e:WB, ELISA\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReactivity\u003c\/b\u003e:Human, Rat, Mouse\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone ID\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eHost\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003eGene Symbol\/ Name\u003c\/b\u003e:Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e:-20°C for 1 year\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification\u003c\/b\u003e:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e:1 mg\/ml\u003c\/p\u003e\u003cp\u003e\u003cb\u003eMolecular weight(Da)\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt accession\u003c\/b\u003e:Human: Q99075; Mouse: Q06186; Rat: Q06175\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSynonyms\u003c\/b\u003e:Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor ;HB-EGF;HBEGF;Diphtheria toxin receptor;DT-R]\u003c\/p\u003e\u003cp\u003e\u003cb\u003eGeneID\u003c\/b\u003e:Human: 1839\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":48650602250340,"sku":"BT-AP09826","price":470.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_4b6837e3-2f2d-4b3e-b9b1-35a5970fef23.jpg?v=1782736198","url":"https:\/\/www.genebiosystems.com\/en-fr\/products\/hbegf-polyclonal-antibody-ab","provider":"GeneBio ","version":"1.0","type":"link"}