{"product_id":"eed-antibody-cat-csb-pa007408esr1hu","title":"EED Antibody - Cat. #: CSB-PA007408ESR1HU","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:50ul\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:eed antibody; EED protein antibody; EED; mouse; homolog of antibody; EED_HUMAN antibody; Embryonic ectoderm development antibody; Embryonic ectoderm development isoform a antibody; Embryonic ECTODERM development protein homolog antibody; Embryonic ectoderm development protein; mouse; homolog of antibody; hEED antibody; OTTHUMP00000235483 antibody; OTTHUMP00000235484 antibody; OTTHUMP00000235485 antibody; Polycomb protein eed antibody; WAIT 1 antibody; WAIT-1 antibody; WAIT1 antibody; WD protein associating with integrin cytoplasmic tails 1 antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:O75530\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Recombinant Human Polycomb protein EED protein (1-300AA)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Polycomb group (PcG) protein. Component of the PRC2\/EED-EZH2 complex, which methylates \\\\\\'Lys-9\\\\\\' and \\\\\\'Lys-27\\\\\\' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes \\\\\\'Lys-26\\\\\\' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 \\\\\\'Lys-27\\\\\\', whereas H3 \\\\\\'Lys-27\\\\\\' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2\/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2\/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:Antigen Affinity Purified\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:Liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:EED\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Epigenetics and Nuclear Signaling\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40486013239396,"sku":"CSB-PA007408ESR1HU","price":331.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_383c6c16-3f92-42a3-aa96-e665f08e73ec.jpg?v=1660139547","url":"https:\/\/www.genebiosystems.com\/en-fr\/products\/eed-antibody-cat-csb-pa007408esr1hu","provider":"GeneBio ","version":"1.0","type":"link"}