{"product_id":"bhlhe41-antibody-cat-csb-pa883658la01hu","title":"BHLHE41 Antibody - Cat. #: CSB-PA883658LA01HU","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:50ug\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:Basic helix-loop-helix domain containing class B3 antibody; BHE41_HUMAN antibody; bHLH protein DEC2 antibody; bHLHB3 antibody; bHLHe41 antibody; Class B basic helix loop helix protein 3 antibody; Class B basic helix-loop-helix protein 3 antibody; Class E basic helix-loop-helix protein 41 antibody; DEC2 antibody; Differentially expressed in chondrocytes protein 2 antibody; Enhancer of split and hairy related protein 1 antibody; Enhancer-of-split and hairy-related protein 1 antibody; hDEC2 antibody; Moderately similar to basic-helix loop helix protein M.musculus antibody; SHARP-1 antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:Q9C0J9\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Recombinant Human Class E basic helix-loop-helix protein 41 protein (185-285AA)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, WB; Recommended dilution: WB:1:500-1:5000\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER\/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1\/2 and CRY1\/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL\/BMAL1 heterodimer by competing for the binding to E-box elements (5\\\\\\'-CACGTG-3\\\\\\') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41\/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA\/B\/G, NR1H3\/LXRA, NR1H4 and VDR transactivation activity.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:\u0026gt;95%, Protein G purified\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Preservative: 0.03% Proclin 300\u003cbr\u003eConstituents: 50% Glycerol, 0.01M PBS, pH 7.4\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:Liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:BHLHE41\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Epigenetics and Nuclear Signaling; Neuroscience; Cancer; Metabolism; Signal transduction\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40487309049956,"sku":"CSB-PA883658LA01HU","price":331.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_48373d88-68fd-4936-b7c4-b6bf03d61e0d.jpg?v=1660162982","url":"https:\/\/www.genebiosystems.com\/en-fr\/products\/bhlhe41-antibody-cat-csb-pa883658la01hu","provider":"GeneBio ","version":"1.0","type":"link"}