{"product_id":"srsf1-antibody-cat-csb-pa021142esr2hu","title":"SRSF1 Antibody - Cat. #: CSB-PA021142ESR2HU","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:50ul\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:Alternative splicing factor 1 antibody; Alternative-splicing factor 1 antibody; arginine\/serine-rich 1 antibody; ASF 1 antibody; ASF antibody; ASF-1 antibody; ASF1 antibody; FLJ53078 antibody; MGC5228 antibody; P33 subunit antibody; Pre mRNA splicing factor SF2 P33 subunit antibody; pre-mRNA-splicing factor SF2 antibody; Serine\/arginine-rich splicing factor 1 antibody; SF2 antibody; SF2P33 antibody; SFRS1 antibody; Splicing factor 2 alternate splicing factor antibody; Splicing factor 2 antibody; Splicing factor antibody; Splicing factor arginine\/serine rich 1 antibody; SR Splicing factor 1 antibody; SRp30a antibody; srsf1 antibody; SRSF1_HUMAN antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:Q07955\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Recombinant Human Serine\/arginine-rich splicing factor 1 protein (1-248AA)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, IHC; Recommended dilution: IHC:1:20-1:200\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5\\\\\\'- and 3\\\\\\'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5\\\\\\'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5\\\\\\'-RGAAGAAC-3\\\\\\' (r=A or G) or the decamers, AGGACAGAGC\/AGGACGAAGC. Binds preferentially to the 5\\\\\\'-CGAGGCG-3\\\\\\' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF\/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP\/NXF1 pathway.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:Antigen Affinity Purified\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:Liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:SRSF1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Epigenetics and Nuclear Signaling\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40486036504676,"sku":"CSB-PA021142ESR2HU","price":331.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_48bf50fe-e4ac-47dd-adae-bce27beb2607.jpg?v=1660139857","url":"https:\/\/www.genebiosystems.com\/en-de\/products\/srsf1-antibody-cat-csb-pa021142esr2hu","provider":"GeneBio ","version":"1.0","type":"link"}