{"product_id":"setd7-antibody-biotin-conjugated-cat-csb-pa840975ld01hu","title":"SETD7 Antibody, Biotin conjugated - Cat. #: CSB-PA840975LD01HU","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:50ug\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:FLJ21193 antibody; H3 K4 HMTase antibody; H3-K4-HMTase SETD7 antibody; H4 lysine 4 specific antibody; Histone H3 K4 methyltransferase antibody; Histone H3 lysine 4 specific methyltransferase antibody; Histone H3-K4 methyltransferase SETD7 antibody; Histone H4 K4 methyltransferase antibody; Histone lysine N methyltransferase antibody; Histone lysine N methyltransferase H3 lysine 4 specific SET7 antibody; Histone-lysine N-methyltransferase SETD7 antibody; KIAA1717 antibody; KMT7 antibody; Lysine methyltransferase antibody; Lysine N-methyltransferase 7 antibody; OTTHUMP00000164543 antibody; OTTHUMP00000220049 antibody; SET 7 antibody; SET 7\/9 antibody; SET 9 antibody; SET D7 antibody; SET domain containing (lysine methyltransferase) 7 antibody; SET domain containing protein 7 antibody; SET domain containing protein 8 antibody; SET domain-containing protein 7 antibody; SET7 antibody; SET7\/9 antibody; SET9 antibody; Setd7 antibody; SETD7_HUMAN antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:Q8WTS6\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Recombinant Human Histone-lysine N-methyltransferase SETD7 protein (1-218AA)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Histone methyltransferase that specifically monomethylates \\\\\\'Lys-4\\\\\\' of histone H3. H3 \\\\\\'Lys-4\\\\\\' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1\/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53\/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates \\\\\\'Lys-189\\\\\\' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates \\\\\\'Lys-372\\\\\\' of p53\/TP53, stabilizing p53\/TP53 and increasing p53\/TP53-mediated transcriptional activation.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:\u0026gt;95%, Protein G purified\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Biotin\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Preservative: 0.03% Proclin 300\u003cbr\u003eConstituents: 50% Glycerol, 0.01M PBS, PH 7.4\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:Liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:SETD7\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Epigenetics and Nuclear Signaling\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40485663080548,"sku":"CSB-PA840975LD01HU","price":331.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_0381bae7-2154-4c03-bb51-a37e0f948706.jpg?v=1660133111","url":"https:\/\/www.genebiosystems.com\/en-de\/products\/setd7-antibody-biotin-conjugated-cat-csb-pa840975ld01hu","provider":"GeneBio ","version":"1.0","type":"link"}