{"product_id":"rnf40-antibody-biotin-conjugated-cat-csb-pa019890ld01hu","title":"RNF40 Antibody, Biotin conjugated - Cat. #: CSB-PA019890LD01HU","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:50ug\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:95 kDa retinoblastoma associated protein antibody; 95 kDa retinoblastoma protein binding protein antibody; 95 kDa retinoblastoma-associated protein antibody; BRE 1B antibody; BRE1 B antibody; BRE1 E3 ubiquitin ligase homolog B antibody; BRE1-B antibody; BRE1B antibody; BRE1B_HUMAN antibody; DKFZp686K191 antibody; E3 ubiquitin protein ligase BRE1B antibody; E3 ubiquitin-protein ligase BRE1B antibody; KIAA0661 antibody; MGC13051 antibody; Rb associated protein antibody; RBP 95 antibody; RBP95 antibody; RING finger protein 40 antibody; Ring finger protein 40 E3 ubiquitin protein ligase antibody; RNF 40 antibody; Rnf40 antibody; STARING antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:O75150\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Recombinant Human E3 ubiquitin-protein ligase BRE1B protein (471-724AA)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Component of the RNF20\/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of \\'Lys-120\\' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 \\'Lys-4\\' and \\'Lys-79\\' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20\/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1\/UBCH are contradictory. Required for transcriptional activation of Hox genes.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:\u0026gt;95%, Protein G purified\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Biotin\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Preservative: 0.03% Proclin 300\u003cbr\u003eConstituents: 50% Glycerol, 0.01M PBS, pH 7.4\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:Liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:RNF40\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Cell biology\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40486654148708,"sku":"CSB-PA019890LD01HU","price":333.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_2c5a5828-9f06-463b-b339-c2e93a86e434.jpg?v=1660150773","url":"https:\/\/www.genebiosystems.com\/en-de\/products\/rnf40-antibody-biotin-conjugated-cat-csb-pa019890ld01hu","provider":"GeneBio ","version":"1.0","type":"link"}