{"product_id":"recombinant-mouse-pglyrp1-pgrp-s-protein-his-tag","title":"Recombinant Mouse PGLYRP1\/PGRP-S Protein (His Tag)","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e: 100μg\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e: 12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e: Recombinant Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e: Others\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e: PGRP;PGRP-S;Pglyrp;Tag7;Tasg7;Tnfsf3l\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Species\u003c\/b\u003e: Mouse\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Host\u003c\/b\u003e: HEK293 Cells\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eFusion tag\u003c\/b\u003e: C-His\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e: O88593\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e: O88593\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e: Peptidoglycan recognition  protein 1, also known as Peptidoglycan recognition protein short, PGRP-S,  PGLYRP1, PGLYRP, PGRP and TNFSF3L, is a secreted protein which belongs to  theN-acetylmuramoyl-L-alanine amidase 2 family. PGLYRP1 \/ PGLYRP is highly  expressed in bone marrow. It is weakly expressed in kidney, liver, small  intestine, spleen, thymus, peripheral leukocyte, lung, fetal spleen and  neutrophils. PGLYRP1 \/ PGLYRP is a pattern receptor that binds to murein  peptidoglycans (PGN) of Gram-positive bacteria. It has bactericidal activity  towards Gram-positive bacteria. PGLYRP1 \/ PGLYRP may kill Gram-positive  bacteria by interfering with peptidoglycan biosynthesis. It binds also to  Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative  bacteria. Peptidoglycan recognition proteins (  PGRPs or PGLYRPs ) are innate immunity proteins that are conserved from insects  to mammals, recognize bacterial peptidoglycan, and function in antibacterial  immunity and inflammation. Mammals have four PGRPs: PGLYRP1, PGLYRP2, PGLYRP3,  and PGLYRP4. They are secreted proteins expressed in polymorphonuclear  leukocytes ( PGLYRP1 ), liver ( PGLYRP2 ), or on body surfaces, mucous  membranes, and in secretions (saliva, sweat) (PGLYRP3 and PGLYRP4). All PGRPs  recognize bacterial peptidoglycan. The PGRPs likely play a role both in  antibacterial defenses and several inflammatory diseases. They modulate local  inflammatory responses in tissues (such as arthritic joints) and there is  evidence for association of PGRPs with inflammatory diseases, such as  psoriasis.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eActivity\u003c\/b\u003e: Not validated for activity\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e: Met 1-Glu 182\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:  \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Lyophilized from PBS, pH 7.4, 10 % glycerol \u003cbr\u003eNormally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.\u003cbr\u003ePlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e: Please refer to the printed manual for detailed information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e:  \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e: 20.2 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e: 18-21 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":47986111479908,"sku":"PKSM040857","price":838.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_745133d5-8d36-4737-a1ab-c25eea35d007.jpg?v=1772482055","url":"https:\/\/www.genebiosystems.com\/en-de\/products\/recombinant-mouse-pglyrp1-pgrp-s-protein-his-tag","provider":"GeneBio ","version":"1.0","type":"link"}