{"product_id":"recombinant-human-thioredoxin-txn-protein","title":"Recombinant Human Thioredoxin\/TXN Protein","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e: 500μg\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e: 12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e: Recombinant Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e: Others\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e: ADF;ATL-Derived Factor;SASP;Surface-Associated Sulphydryl Protein;TRDX;TRX;TRX1;TXN;Thioredoxin;Trx\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e: Signal Transduction;metabolism;\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Species\u003c\/b\u003e: Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Host\u003c\/b\u003e: E.coli\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: Enzyme\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFusion tag\u003c\/b\u003e: None\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e: P10599\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e: P10599\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e: Thioredoxin; also known as  ATL-derived factor; Surface-associated sulphydryl protein; SASP and TXN; is a  nucleus; cytoplasm and secreted protein which belongs to thethioredoxin  family. Thioredoxins are proteins that act as antioxidants by facilitating the  reduction of other proteins by cysteine thiol-disulfide exchange. Thioredoxins  are found in nearly all known organisms and are essential for life in mammals.  Thioredoxin \/ TXN participates in various redox reactions through the  reversible oxidation of its active center dithiol to a disulfide and catalyzes  dithiol-disulfide exchange reactions. Thioredoxin \/ TXN plays a role in the  reversible S-nitrosylation of cysteine residues in target proteins; and thereby  contributes to the response to intracellular nitric oxide. Thioredoxin \/ TXN  nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO); and  thereby inhibits caspase-3 activity. Thioredoxin \/ TXN induces the FOS\/JUN AP-1  DNA-binding activity in ionizing radiation (IR) cells through its  oxidation\/reduction status and stimulates AP-1 transcriptional activity.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eActivity\u003c\/b\u003e: Measured by its ability to catalyze the reduction of insulin. The reaction leads toprecipitation, which can be measured by absorbance at 650 nm. The specific activity is 5-10 A650\/min\/mg. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e: Met 1-Val 105\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:  \u0026gt; 97 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Lyophilized from sterile PBS, pH 7.5\u003cbr\u003eNormally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.\u003cbr\u003ePlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e: Please refer to the printed manual for detailed information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e: Please contact us for more information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e: 11.7 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e: 14 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":47972827693156,"sku":"PKSH030450","price":2883.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_230ff395-bdfb-447f-9644-c9314b8d7732.jpg?v=1772198407","url":"https:\/\/www.genebiosystems.com\/en-de\/products\/recombinant-human-thioredoxin-txn-protein","provider":"GeneBio ","version":"1.0","type":"link"}