{"product_id":"recombinant-human-serpinb6-pi-6-protein-his-tag","title":"Recombinant Human SerpinB6\/PI-6 Protein (His Tag)","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e: 50μg\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e: 12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e: Recombinant Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e: Others\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e: CAP;Cytoplasmic Antiproteinase;PI-6;PI6;PTI;Peptidase Inhibitor 6;Placental Thrombin Inhibitor;RP1-90J20.6;SERPINB6;SPI3;Serpin B6\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e: Cell Biology\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Species\u003c\/b\u003e: Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Host\u003c\/b\u003e: Baculovirus-Insect Cells\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eFusion tag\u003c\/b\u003e: N-His\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e: P35237\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e: AAB30320.1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e: SerpinB6,  also known as Cytoplasmic antiproteinase, Peptidase inhibitor 6, Placental  thrombin inhibitor, SERPINB6 and PI-6, is a cytoplasm protein which belongs to  theserpin family and Ov-serpin subfamily. SerpinB6 \/ PI-6 is an inhibitor  of cathepsin G, kallikrein-8 and thrombin. It may play an important role in the  inner ear in the protection against leakage of lysosomal content during stress  and loss of this protection results in cell death and sensorineural hearing  loss. SerpinB6 \/ PI-6 is expressed in keratinocytes (at protein level). It is  also found in placenta, cardiac muscle, lung, liver, kidney and pancreas.  SerpinB6 \/ PI-6 is expressed in the inner ear hair cells. It expressed  abundantly by normal mast cells in different tissues and by mast cells in  mastocytoma lesions. SerpinB6 \/ PI-6 may be involved in the regulation of  serine proteinases present in the brain or extravasated from the blood. Defects  in SerpinB6 are the cause of deafness autosomal recessive type 91 which is a  form of non-syndromic deafness characterized by progressive and age-dependent  sensorineural hearing loss. Vestibular function is normal.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eActivity\u003c\/b\u003e: Not validated for activity\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e: Asp 2-Pro 376\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:  \u0026gt; 90 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Lyophilized from sterile PBS, pH 7.4\u003cbr\u003eNormally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.\u003cbr\u003ePlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e: Please refer to the printed manual for detailed information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e:  \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e: 44.9 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e: 43 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":47972846829668,"sku":"PKSH030778","price":838.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_cbab2bf9-a5d2-44c0-a1a0-d1cb6bb6a3fd.jpg?v=1772200143","url":"https:\/\/www.genebiosystems.com\/en-de\/products\/recombinant-human-serpinb6-pi-6-protein-his-tag","provider":"GeneBio ","version":"1.0","type":"link"}