{"product_id":"recombinant-human-ruvb-like-2ruvbl2","title":"Recombinant Human RuvB-like 2(RUVBL2)","description":"\u003cp\u003e\u003cb\u003e\u0026gt;Several Other Sizes Are Also Available. Please Inquire.  Default Size\u003c\/b\u003e: 200ug\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUpdated Date\u003c\/b\u003e: Stock Protein updated on 20170405\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch areas\u003c\/b\u003e: Epigenetics and Nuclear Signaling\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget \/ Protein\u003c\/b\u003e: RUVBL2\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBiologically active\u003c\/b\u003e: Not Tested\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression system\u003c\/b\u003e: E.coli\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies of origin\u003c\/b\u003e: Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eDelivery time\u003c\/b\u003e: 3-7 business days\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniprot ID\u003c\/b\u003e: Q9Y230\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAA Sequence\u003c\/b\u003e: ATVTATTKVPEIRDVTRIERIGAHSHIRGLGLDDALEPRQASQGMVGQLAARRAAGVVLEMIREGKIAGRAVLIAGQPGTGKTAIAMGMAQALGPDTPFTAIAGSEIFSLEMSKTEALTQAFRRSIGVRIKEETEIIEGEVVEIQIDRPATGTGSKVGKLTLKTTEMETIYDLGTKMIESLTKDKVQAGDVITIDKATGKISKLGRSFTRARDYDAMGSQTKFVQCPDGELQKRKEVVHTVSLHEIDVINSRTQGFLALFSGDTGEIKSEVREQINAKVAEWREEGKAEIIPGVLFIDEVHMLDIESFSFLNRALESDMAPVLIMATNRGITRIRGTSYQSPHGIPIDLLDRLLIVSTTPYSEKDTKQILRIRCEEEDVEMSEDAYTVLTRIGLETSLRYAIQLITAASLVCRKRKGTEVQVDDIKRVYSLFLDESRSTQYMKEYQDAFLFNELKGETMDTS\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTag info\u003c\/b\u003e: N-terminal 6xHis-SUMO-tagged\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Region\u003c\/b\u003e: 2-463aa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProtein length\u003c\/b\u003e: Full Length\u003c\/p\u003e\u003cp\u003e\u003cb\u003eMW\u003c\/b\u003e: 67 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAlternative Name(s)\u003c\/b\u003e: 48 kDa TATA box-binding protein-interacting protein\nShort name:\n48 kDa TBP-interacting protein\n51 kDa erythrocyte cytosolic protein\nShort name:\nECP-51\nINO80 complex subunit J\nRepressing pontin 52\nShort name:\nReptin 52\nTIP49b\nTIP60-associated protein 54-beta\nShort name:\nTAP54-beta\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRelevance\u003c\/b\u003e: Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity.\nComponent of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z\/H2AFZ from the nucleosome.\nProposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.\nPlays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1\/TCF1-CTNNB1 complex. May also inhibit the transcriptional activity of ATF2.\nInvolved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReference\u003c\/b\u003e: \"Genome-wide screen identifies a novel p97\/CDC-48-dependent pathway regulating ER-stress-induced gene transcription.\"Marza E., Taouji S., Barroso K., Raymond A.A., Guignard L., Bonneu M., Pallares-Lupon N., Dupuy J.W., Fernandez-Zapico M.E., Rosenbaum J., Palladino F., Dupuy D., Chevet E.EMBO Rep. 16:332-340(2015)\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e: Greater than 90% as determined by SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. \nGenerally, the shelf life of liquid form is 6 months at -20℃\/-80℃. The shelf life of lyophilized form is 12 months at -20℃\/-80℃.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eNotes\u003c\/b\u003e: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":39766632726628,"sku":"CSB-EP897459HU","price":870.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_d093d638-12cf-4527-8f0a-bc22b99ba4e5.jpg?v=1659192315","url":"https:\/\/www.genebiosystems.com\/en-de\/products\/recombinant-human-ruvb-like-2ruvbl2","provider":"GeneBio ","version":"1.0","type":"link"}