{"product_id":"recombinant-human-pde2a-cgs-pde-protein-aa-215-900-his-tag","title":"Recombinant Human PDE2A\/CGS-PDE Protein (aa 215-900, His Tag)","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e: 50μg\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e: 12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e: Recombinant Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e: Others\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e: CGS-PDE;PDE2A1;PED2A4;cGSPDE\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e: Signal Transduction\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Species\u003c\/b\u003e: Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Host\u003c\/b\u003e: Baculovirus-Insect Cells\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eFusion tag\u003c\/b\u003e: C-His\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e: O00408\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e: O00408-1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e: cGMP-dependent  3',5'-cyclic phosphodiesterase, also known as cyclic GMP-stimulated  phosphodiesterase and PDE2A, is a peripheral membrane protein which belongs to  thecyclic nucleotide phosphodiesterase family and PDE2 subfamily.  Phosphodiesterases (PDEs) comprise a family of enzymes that regulate the levels  of cyclic nucleotides, key second messengers that mediate a diverse array of  functions. Phosphodiesterases (PDEs) modulate signaling by cyclic nucleotides  in diverse processes such as cardiac contractility, platelet aggregation,  lipolysis, glycogenolysis, and smooth muscle contraction. PDE2A is an  evolutionarily conserved cGMP-stimulated cAMP and cGMP PDE. PDE2A contains  twoGAF domains. PDE2A is expressed in brain and to a lesser extent in  heart, placenta, lung, skeletal muscle, kidney and pancreas. PDE2A is a cyclic  nucleotide phosphodiesterase with a dual-specificity for the second messengers  cAMP and cGMP, which are key regulators of many important physiological  processes. PDE2A is involved in the regulation of blood pressure and fluid  homeostasis by the atrial natriuretic peptide (ANP), making PDE2-type enzymes  important targets for drug discovery.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eActivity\u003c\/b\u003e: Not validated for activity\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e: Glu 215-His 900\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:  \u0026gt; 90 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% glycerol\u003cbr\u003eNormally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.\u003cbr\u003ePlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e: Please refer to the printed manual for detailed information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e:  \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e: 80.0 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e: 66 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":47972845518948,"sku":"PKSH030756","price":838.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_339381a1-778b-4523-bdd3-eaa0904140c0.jpg?v=1772200009","url":"https:\/\/www.genebiosystems.com\/en-de\/products\/recombinant-human-pde2a-cgs-pde-protein-aa-215-900-his-tag","provider":"GeneBio ","version":"1.0","type":"link"}