{"product_id":"recombinant-human-nrxn3-protein-fc-tag","title":"Recombinant Human NRXN3 Protein (Fc Tag)","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e: 100μg\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e: 12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e: Recombinant Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e: Others\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e: C14orf60\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e: Neuroscience\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Species\u003c\/b\u003e: Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Host\u003c\/b\u003e: HEK293 Cells\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: Cell culture\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFusion tag\u003c\/b\u003e: C-hFc\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e: Q9HDB5\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e: NP_620426.2\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e: Neurexin-3-beta; also known as  Neurexin III-beta and NRXN3; is a single-pass type I membrane protein which  belongs to theneurexin family. It contains onelaminin G-like  domain. It is a neuronal cell surface protein that may be involved in cell  recognition and cell adhesion. Neurexins are a family of proteins that function  in the vertebrate nervous system as cell adhesion molecules and receptors. They  are encoded by several unlinked genes of which two; NRXN1 and NRXN3; are among  the largest known human genes. Three of the genes ( NRXN1; NRXN2; NRXN3 )  utilize two alternate promoters and include numerous alternatively spliced  exons to generate thousands of distinct mRNA transcripts and protein isoforms.  The majority of transcripts are produced from the upstream promoter and encode  alpha-neurexin isoforms; a much smaller number of transcripts are produced from  the downstream promoter and encode beta-neurexin isoforms. The alpha-neurexins  contain EGF-like sequences and laminin G domains; and have been shown to  interact with neurexophilins. The beta-neurexins lack EGF-like sequences and  contain fewer laminin G domains than alpha-neurexins. NRXN3 have been linked to  genetic predisposition towards a number of conditions such as alcohol or drug  addiction; or obesity.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eActivity\u003c\/b\u003e: Measured by the ability of the immobilized protein to support the adhesion of C6 Rat brain glial cells. When 5 x 10\u003csup\u003e4\u003c\/sup\u003e cells\/well are added to NRXN3 coated plates (0.8 μg\/ml and 100 μl\/well), \u0026gt; 30 % will adhere specifically after 60 minutes at 37℃. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e: Met 1-Thr 357\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:  \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Lyophilized from sterile PBS, pH 7.4\u003cbr\u003eNormally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.\u003cbr\u003ePlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e: Please refer to the printed manual for detailed information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e:  \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e: 61.6 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e: 75-85 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":47972886315108,"sku":"PKSH030985","price":714.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_a6bfd761-4ce0-42d9-af5e-52c1c4bf9ff3.jpg?v=1772201239","url":"https:\/\/www.genebiosystems.com\/en-de\/products\/recombinant-human-nrxn3-protein-fc-tag","provider":"GeneBio ","version":"1.0","type":"link"}