{"product_id":"recombinant-human-mek2-map2k2-mkk2-protein-gst-tag","title":"Recombinant Human MEK2\/MAP2K2\/MKK2 Protein (GST Tag)","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e: 50μg\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e: 12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e: Recombinant Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e: Others\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e: CFC4;FLJ26075;MAPKK2;MEK2;MKK2;PRKMK2\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e: Signal Transduction;Cancer;\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Species\u003c\/b\u003e: Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Host\u003c\/b\u003e: Baculovirus-Insect Cells\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eFusion tag\u003c\/b\u003e: N-GST\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e: P36507\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e: NP_109587.1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e: Dual  specificity mitogen-activated protein kinase kinase 2, also known as MAP kinase  kinase 2, MAPKK2, ERK activator kinase 2, MAPK \/ ERK kinase 2, MEK2 and MAP2K2,  is a member of the protein kinase superfamily, STE Ser\/Thr protein kinase  family and MAP kinase kinase subfamily. MAP2K2 \/ MEK2 contains oneprotein  kinase domain. MEK1 and MEK2 (also known as MAP2K1 and MAP2K2, respectively)  are evolutionarily conserved, dual-specificity kinases that mediate Erk1 and  Erk2 activation during adhesion and growth factor signaling. MAP2K1 \/ MEK1 is a  crucial modulator of Mek and Erk signaling and have potential implications for  the role of MEK1 and MEK2 in tumorigenesis. MAP2K2 \/ MEK2 catalyzes the  concomitant phosphorylation of a threonine and a tyrosine residue in a  Thr-Glu-Tyr sequence located in MAP kinases. It also activates the ERK1 and  ERK2 MAP kinases. Defects in MAP2K2 are a cause of cardiofaciocutaneous  syndrome (CFC syndrome) which is characterized by a distinctive facial  appearance, heart defects and mental retardation. Heart defects include  pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eActivity\u003c\/b\u003e: Not validated for activity\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e: Met 1-Val 400\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:  \u0026gt; 92 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Lyophilized from sterile 20mM Tris, 500mM NaCl, 2mM GSH, pH 7.4\u003cbr\u003eNormally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.\u003cbr\u003ePlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e: Please refer to the printed manual for detailed information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e:  \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e: 70.7 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e: 66 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":47973030396004,"sku":"PKSH031494","price":539.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_67d3003a-2b80-40c8-9dc8-336dd4a37139.jpg?v=1772203774","url":"https:\/\/www.genebiosystems.com\/en-de\/products\/recombinant-human-mek2-map2k2-mkk2-protein-gst-tag","provider":"GeneBio ","version":"1.0","type":"link"}