{"product_id":"phospho-tcf3-thr355-antibody-cat-csb-pa123008","title":"Phospho-TCF3 (Thr355) Antibody - Cat. #: CSB-PA123008","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:100ul\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:AGM8 antibody; bHLHb21 antibody; Class B basic helix-loop-helix protein 21 antibody; E12 antibody; E2A antibody; E2A immunoglobulin enhancer binding factors E12\/E47 antibody; E47 antibody; Helix loop helix protein HE47 antibody; Immunoglobulin enhancer-binding factor E12\/E47 antibody; Immunoglobulin transcription factor 1 antibody; ITF1 antibody; Kappa-E2-binding factor antibody; MGC129647 antibody; MGC129648 antibody; Negative vitamin D response element binding protein antibody; NOL1-TCF3 fusion antibody; TCF-3 antibody; Tcf3 antibody; TFE2_HUMAN antibody; transcription factor 3 (E2A immunoglobulin enhancer binding factors E12\/E47) antibody; Transcription factor 3 antibody; transcription factor 3 variant 3 antibody; Transcription factor E2-alpha antibody; Transcription factor ITF-1 antibody; VDIR antibody; VDR interacting repressor antibody; vitamin D receptor-interacting repressor antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:P15923\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Peptide sequence around phosphorylation site of threonine 355 (P-S-T(p)-P-V) derived from Human  E2A .\n\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human, Mouse, Rat\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, IHC; IHC:1:50-1:100\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003eE2A is a transcription factor that plays major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Heterodimers between E2A and tissue-specific basic helix-loop-helix (bHLH) Dimers bind DNA on E-box motifs: 5'- CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Deletions in E2A have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Two alternatively spliced human isoforms have been described. \u003cbr\u003e\u003cbr\u003eKamps M.P., Cell 60:547-555(1990).\u003cbr\u003eNourse J., Cell 60:535-545(1990).\u003cbr\u003eGrimwood J., Nature 428:529-535(2004).\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:TCF3\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Epigenetics and Nuclear Signaling;Stem cells\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40484032315492,"sku":"CSB-PA123008","price":719.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_537d13f1-d8a5-4a56-b1dd-91af76dcbdb4.jpg?v=1660086511","url":"https:\/\/www.genebiosystems.com\/en-de\/products\/phospho-tcf3-thr355-antibody-cat-csb-pa123008","provider":"GeneBio ","version":"1.0","type":"link"}