{"product_id":"phospho-runx1-ser435-antibody-cat-csb-pa110286","title":"Phospho-RUNX1 (Ser435) Antibody - Cat. #: CSB-PA110286","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:100ul\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:Acute myeloid leukemia 1 antibody; Acute myeloid leukemia 1 protein antibody; alpha subunit core binding factor antibody; AML 1 antibody; AML1 antibody; AML1 EVI 1 antibody; AML1 EVI 1 fusion protein antibody; Aml1 oncogene antibody; AMLCR 1 antibody; AMLCR1 antibody; CBF alpha 2 antibody; CBF-alpha-2 antibody; CBFA 2 antibody; CBFA2 antibody; Core binding factor alpha 2 subunit antibody; Core binding factor runt domain alpha subunit 2 antibody; Core-binding factor subunit alpha-2 antibody; EVI 1 antibody; EVI1 antibody; HGNC antibody; Oncogene AML 1 antibody; Oncogene AML-1 antibody; OTTHUMP00000108696 antibody; OTTHUMP00000108697 antibody; OTTHUMP00000108699 antibody; OTTHUMP00000108700 antibody; OTTHUMP00000108702 antibody; PEA2 alpha B antibody; PEA2-alpha B antibody; PEBP2 alpha B antibody; PEBP2-alpha B antibody; PEBP2A2 antibody; PEBP2aB antibody; Polyomavirus enhancer binding protein 2 alpha B subunit antibody; Polyomavirus enhancer-binding protein 2 alpha B subunit antibody; Run1 antibody; Runt related transcription factor 1 antibody; Runt-related transcription factor 1 antibody; RUNX 1 antibody; Runx1 antibody; RUNX1_HUMAN antibody; SL3 3 enhancer factor 1 alpha B subunit antibody; SL3-3 enhancer factor 1 alpha B subunit antibody; SL3\/AKV core binding factor alpha B subunit antibody; SL3\/AKV core-binding factor alpha B subunit antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:Q01196\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Peptide sequence around phosphorylation site of Serine 435( S-N-S(p)-P-T) derived from Human AML1.\n\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human, Mouse, Rat\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, WB; WB:1:500-1:1000\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003eCBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits MYST4-dependent transcriptional activation.\u003cbr\u003e\u003cbr\u003eMiyoshi H., Proc. Natl. Acad. Sci. U.S.A. 88:10431-10434(1991).\u003cbr\u003eSacchi N., Genes Chromosomes Cancer 11:226-236(1994).\u003cbr\u003eNucifora G., Blood 81:2728-2734(1993).\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:RUNX1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Epigenetics and Nuclear Signaling?Neuroscience?Cancer;Developmental biology;Stem cells\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40484031561828,"sku":"CSB-PA110286","price":719.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_91dfa473-c38e-4b08-a8fb-32ccab41195d.jpg?v=1660086494","url":"https:\/\/www.genebiosystems.com\/en-de\/products\/phospho-runx1-ser435-antibody-cat-csb-pa110286","provider":"GeneBio ","version":"1.0","type":"link"}