{"product_id":"phospho-ntrk1-ser791-antibody-cat-csb-pa198739","title":"Phospho-NTRK1 (Ser791) Antibody - Cat. #: CSB-PA198739","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:100ul\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:gp140trk antibody; High affinity nerve growth factor receptor antibody; High affinity nerve growth factor receptor precursor antibody; MTC antibody; Neurotrophic tyrosine kinase receptor type 1 antibody; NTRK1 antibody; NTRK1_HUMAN antibody; Oncogene TRK antibody; p14-TrkA antibody; p140 TrkA antibody; p140-TrkA antibody; Slow nerve growth antibody; Trk A antibody; TRK antibody; Trk-A antibody; TRK1 antibody; TRK1-transforming tyrosine kinase protein antibody; Tropomyosin-related kinase A antibody; Tyrosine kinase receptor A antibody; Tyrosine kinase receptor antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:P04629\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Peptide sequence around phosphorylation site of tyrosine791 (P-V-Y(p)-L-D) derived from Human TrkA.\n\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, WB, IF; WB:1:500-1:1000, IF:1:100-1:200\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4\/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.\u003cbr\u003e\u003cbr\u003eWiese S, et al. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):17210-5.\u003cbr\u003eValdez G, et al. Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12270-5\u003cbr\u003eInoue K, et al. J Biol Chem. 2007 Aug 17;282(33):24175-84\u003cbr\u003e\n\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Supplied at 1.0mg\/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:NTRK1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Others\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40484042440804,"sku":"CSB-PA198739","price":724.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_6602aaf4-8c39-4326-882d-ff12d4cb01a1.jpg?v=1660086793","url":"https:\/\/www.genebiosystems.com\/en-de\/products\/phospho-ntrk1-ser791-antibody-cat-csb-pa198739","provider":"GeneBio ","version":"1.0","type":"link"}