{"product_id":"phospho-epb41-tyr660-418-antibody-cat-csb-pa242308","title":"Phospho-EPB41 (Tyr660\/418) Antibody - Cat. #: CSB-PA242308","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:100ul\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:4.1R antibody; 41_HUMAN antibody; Band 4.1 antibody; E41P antibody; EL 1 antibody; EL1 antibody; EL1 gene antibody; Elliptocytosis 1 antibody; Elliptocytosis 1 RH linked antibody; EPB 4.1 antibody; EPB 41 antibody; EPB4.1 antibody; Epb41 antibody; Erythrocyte membrane protein band 4.1 (elliptocytosis 1 RH linked) antibody; Erythrocyte membrane protein band 4.1 antibody; Erythrocyte surface protein band 4.1 antibody; HE antibody; P4.1 antibody; Protein 4.1 antibody; Protein 4.1; red blood cell type antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:P11171\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Peptide sequence around phosphorylation site of tyrosine 660\/418 (N-I-Y(p)-I-R)derived from Human EPB41.\n\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human, Mouse\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, WB; WB:1:500-1:1000\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003eElliptocytosis is a hematologic disorder characterized by elliptically shaped erythrocytes and a variable degree of hemolytic anemia. Inherited as an autosomal dominant, elliptocytosis results from mutation in any one of several genes encoding proteins of the red cell membrane skeleton. The form discussed here is the one found in the 1950s to be linked to Rh blood group and more recently shown to be caused by a defect in protein 4.1. 'Rh-unlinked' forms of elliptocytosis are caused by mutation in the alpha-spectrin gene, the beta-spectrin gene, or the band 3 gene.\u003cbr\u003e\u003cbr\u003eConboy J.G.,  Proc. Natl. Acad. Sci. U.S.A. 83:9512-9516(1986).\u003cbr\u003eTang T.K., Adv. Exp. Med. Biol. 241:81-95(1988).\u003cbr\u003eTang T.K., Proc. Natl. Acad. Sci. U.S.A. 85:3713-3717(1988).\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:EPB41\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Cardiovascular;Signal transduction\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40484032348260,"sku":"CSB-PA242308","price":722.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_42944bca-4f87-49fb-9db1-5e12176adebd.jpg?v=1660086512","url":"https:\/\/www.genebiosystems.com\/en-de\/products\/phospho-epb41-tyr660-418-antibody-cat-csb-pa242308","provider":"GeneBio ","version":"1.0","type":"link"}