MARK1 Antibody - Cat. #: CSB-PA873719DSR1HU

SKU: CSB-PA873719DSR1HU

Size :50ul

Clone Number:

Aliases:KIAA1477 antibody; MAP/microtubule affinity regulating kinase 1 antibody; MAP/microtubule affinity-regulating kinase 1 antibody; MARK 1 antibody; MARK antibody; Mark1 antibody; MARK1_HUMAN antibody; MGC126512 antibody; MGC126513 antibody; Serine/threonine protein kinase MARK1 antibody; Serine/threonine-protein kinase MARK1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9P0L2

Immunogen:Recombinant Human Serine/threonine-protein kinase MARK1 protein (560-700AA)

Raised in:Rabbit

Species Reactivity:Human, Rat

Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

Background:Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:MARK1

Research Areas:Signal transduction