{"product_id":"human-transient-receptor-potential-cation-channel-subfamily-v-member-4-trpv4-elisa-kit","title":"Human Transient Receptor Potential Cation Channel Subfamily V Member 4, TRPV4 ELISA Kit","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e:96 Tests-1 Kit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:18826956, PubMed:18695040, PubMed:29899501).\n\nAlso activated by heat, low pH, citrate and phorbol esters (PubMed:16293632, PubMed:18826956, PubMed:18695040, PubMed:25256292, PubMed:20037586, PubMed:21964574).\n\nIncrease of intracellular Ca2+ potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (PubMed:12724311, PubMed:18826956).\n\nPromotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and\/or maintenance of functional intercellular barriers (By similarity).\n\nActs as a regulator of intracellular Ca2+ in synoviocytes (PubMed:19759329).\n\nPlays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (PubMed:19759329).\n\nTogether with PKD2, forms mechano- and thermosensitive channels in cilium (PubMed:18695040).\n\nNegatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (By similarity).\n\nRegulates expression of chemokines and cytokines related to proinflammatory pathway in adipocytes (By similarity).\n\nTogether with AQP5, controls regulatory volume decrease in salivary epithelial cells (By similarity).\n\nRequired for normal development and maintenance of bone and cartilage (PubMed:26249260).\n\nIn its inactive state, may sequester DDX3X at the plasma membrane. When activated, the interaction between both proteins is affected and DDX3X relocalizes to the nucleus (PubMed:29899501).\n\nNon-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by phorbol esters. Has the same channel activity as isoform 1, and is activated by the same stimuli.\n\nLacks channel activity, due to impaired oligomerization and intracellular retention.\n\nLacks channel activity, due to impaired oligomerization and intracellular retention.\n\nLacks channel activity, due to impaired oligomerization and intracellular retention.\n\n(Microbial infection) Facilitates hepatitis C virus (HCV) replication, possibly through its action on DDX3X.\n\n(Microbial infection) Facilitates Dengue virus (DENV) replication, possibly through its action on DDX3X.\n\n(Microbial infection) Facilitates Zika virus (ZIKV) replication, possibly through its action on DDX3X.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch_area\u003c\/b\u003e:Others\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplications\u003c\/b\u003e:ELISA\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget_protein\u003c\/b\u003e:TrpV4\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReactivity\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAssay type\u003c\/b\u003e:Sandwich\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSensitivity\u003c\/b\u003e:4.99ng\/L\u003c\/p\u003e\u003cp\u003e\u003cb\u003eDetection range\u003c\/b\u003e:10-2000ng\/L\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSample type\u003c\/b\u003e:Serum, plasma or other biological fluids\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFull product name\u003c\/b\u003e:Transient receptor potential cation Channel subfamily V member 4\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e:2-8ºC\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAssay time\u003c\/b\u003e:1h 30m\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt accession\u003c\/b\u003e:Q9HBA0\u003c\/p\u003e\u003cp\u003e\u003cb\u003eMASS(Da)\u003c\/b\u003e:98,281\u003c\/p\u003e\u003cp\u003e\u003cb\u003eGeneID\u003c\/b\u003e:59341\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSynonyms\u003c\/b\u003e:BCYM3;CMT2C;HMSN2C;Osm-9-like TRP Channel 4;OTRPC4;SMAL;SPSMA;SSQTL1;Transient receptor potential cation Channel subfamily V member 4;Transient receptor potential protein 12;TRP12;TrpV4;Vanilloid receptor-like Channel 2;Vanilloid receptor-like protein 2;Vanilloid receptor-related osmotically-activated Channel;VRL2;VRL-2;VR-OAC\u003c\/p\u003e\u003cp\u003e\u003cb\u003eGene names\u003c\/b\u003e:TRPV4\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStandard solution\u003c\/b\u003e:2400ng\/L\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":48648160641124,"sku":"E6305Hu","price":696.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_b10c7321-8ae9-4771-a036-3fea9dedf275.jpg?v=1782710575","url":"https:\/\/www.genebiosystems.com\/en-de\/products\/human-transient-receptor-potential-cation-channel-subfamily-v-member-4-trpv4-elisa-kit","provider":"GeneBio ","version":"1.0","type":"link"}