{"product_id":"eri1-antibody-biotin-conjugated-cat-csb-pa22449d0rb","title":"ERI1 Antibody, Biotin conjugated - Cat. #: CSB-PA22449D0Rb","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:50ug\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:3' 5' exonuclease ERI 1 antibody; 3' 5' exonuclease ERI1 antibody; 3' EXO antibody; 3' exoribonuclease antibody; 3' HEXO antibody; 3' histone mRNA exonuclease 1 antibody; 3''-5'' exonuclease eri1 antibody; 3''-5'' exoribonuclease 1 antibody; 3'EXO antibody; 3'HEXO antibody; ERI 1 antibody; Eri 1 homolog antibody; Eri-1 homolog antibody; eri1 antibody; Eri1 homolog antibody; ERI1_HUMAN antibody; HEXO antibody; Histone mRNA 3' end specific exonuclease antibody; Histone mRNA 3' end specific exoribonuclease antibody; Histone mRNA 3''-end-specific exoribonuclease antibody; Histone mRNA 3''-exonuclease 1 antibody; MGC35395 antibody; Protein 3''hExo antibody; THEX 1 antibody; THEX1 antibody; Three prime histone mRNA exonuclease 1 antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:Q8IV48\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Recombinant Human 3\\'-5\\' exoribonuclease 1 protein (2-66AA)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:RNA exonuclease that binds to the 3\\'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2\\' and 3\\'-hydroxyl groups at the last nucleotide of the histone 3\\'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3\\'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5\\'-ACCCA-3\\' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3\\'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:\u0026gt;95%, Protein G purified\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Biotin\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Preservative: 0.03% Proclin 300\u003cbr\u003eConstituents: 50% Glycerol, 0.01M PBS, pH 7.4\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:Liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:ERI1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Epigenetics and Nuclear Signaling\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40487221297252,"sku":"CSB-PA22449D0Rb","price":331.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_9de4226d-e743-4877-9d49-7eeec127ccac.jpg?v=1660161272","url":"https:\/\/www.genebiosystems.com\/en-de\/products\/eri1-antibody-biotin-conjugated-cat-csb-pa22449d0rb","provider":"GeneBio ","version":"1.0","type":"link"}