{"product_id":"ccnd1-antibody-cat-csb-pa004811ka01hu","title":"CCND1 Antibody - Cat. #: CSB-PA004811KA01HU","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:100ul\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:AI327039 antibody; B cell CLL\/lymphoma 1 antibody; B cell leukemia 1 antibody; B cell lymphoma 1 protein antibody; B-cell lymphoma 1 protein antibody; BCL 1 antibody; BCL-1 antibody; BCL-1 oncogene antibody; BCL1 antibody; BCL1 oncogene antibody; ccnd1 antibody; CCND1\/FSTL3 fusion gene antibody; CCND1\/FSTL3 fusion gene; included antibody; CCND1\/IGHG1 fusion gene antibody; CCND1\/IGHG1 fusion gene; included antibody; CCND1\/IGLC1 fusion gene antibody; CCND1\/IGLC1 fusion gene; included antibody; CCND1\/PTH fusion gene antibody; CCND1\/PTH fusion gene; included antibody; CCND1_HUMAN antibody; cD1 antibody; Cyl 1 antibody; D11S287E antibody; G1\/S specific cyclin D1 antibody; G1\/S-specific cyclin-D1 antibody; Parathyroid adenomatosis 1 antibody; PRAD1 antibody; PRAD1 oncogene antibody; U21B31 antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:P24385\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:A synthetic peptide of Human Cyclin D1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human, Mouse, Rat\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, WB, IHC, ICC, IP; WB:1:500-1:1000, IHC:1:50-1:100, ICC:1:50-1:100, IP:1:20-1:50\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Activity of the cyclin-dependent kinases CDK4 and CDK6 is regulated by T-loop phosphorylation, by the abundance of their cyclin partners (the D-type cyclins), and by association with CDK inhibitors of the Cip\/Kip or INK family of proteins. The inactive ternary complex of cyclin D\/CDK4 and p27 Kip1 requires extracellular mitogenic stimuli for the release and degradation of p27 concomitant with a rise in cyclin D levels to effect progression through the restriction point and pRb-dependent entry into S-phase. The active complex of cyclin D\/CDK4 targets the retinoblastoma protein for phosphorylation, allowing the release of E2F transcription factors that activate G1\/S-phase gene expression. Levels of cyclin D protein drop upon withdrawal of growth factors through downregulation of its protein expression and through phosphorylation-dependent degradation.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:Affinity purification\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Store at -20°C or -80°C. Avoid freeze \/ thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:CCND1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Epigenetics and Nuclear Signaling;Cancer;Cell biology\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40483674488932,"sku":"CSB-PA004811KA01HU","price":795.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_684528c1-f4be-43f0-a8a4-2d95ae12d547.jpg?v=1660073568","url":"https:\/\/www.genebiosystems.com\/en-de\/products\/ccnd1-antibody-cat-csb-pa004811ka01hu","provider":"GeneBio ","version":"1.0","type":"link"}