{"product_id":"camk1-antibody-cat-csb-pa614509la01hu","title":"CAMK1 Antibody - Cat. #: CSB-PA614509LA01HU","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:50ug\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:Calcium \/ calmodulin dependent protein kinase 1 antibody; Calcium \/ calmodulin dependent protein kinase I antibody; Calcium \/ calmodulin dependent protein kinase type 1 antibody; Calcium\/calmodulin dependent protein kinase 1 antibody; Calcium\/calmodulin dependent protein kinase I antibody; Calcium\/calmodulin dependent protein kinase type 1 antibody; Calcium\/calmodulin-dependent protein kinase type 1 antibody; CaM K1 antibody; CaM KI antibody; CaM kinase 1 alpha antibody; CAM kinase 1 antibody; CaM kinase I alpha antibody; CaM kinase I antibody; CaM-KI antibody; CaMK 1 antibody; CAMK I antibody; CaMK1 alpha antibody; CAMK1 antibody; CAMK1 PEN antibody; CaMKI alpha antibody; CaMKI-alpha antibody; KCC1A_HUMAN antibody; MGC120317 antibody; MGC120318 antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:Q14012\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Recombinant Human Calcium\/calmodulin-dependent protein kinase type 1 protein (166-265AA)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human, Mouse, Rat\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, WB, IF; Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Calcium\/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7\/BETAPIX on \\\\\\'Ser-694\\\\\\', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on \\\\\\'Ser-91\\\\\\', \\\\\\'Ser-92\\\\\\', \\\\\\'Ser-93\\\\\\' and \\\\\\'Ser-294\\\\\\'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of \\\\\\'Ser-259\\\\\\' and \\\\\\'Ser-498\\\\\\' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on \\\\\\'Ser-276\\\\\\' and \\\\\\'Ser-295\\\\\\'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7\/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1\/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3\/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1\/synapsin I.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:\u0026gt;95%, Protein G purified\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Preservative: 0.03% Proclin 300\u003cbr\u003eConstituents: 50% Glycerol, 0.01M PBS, pH 7.4\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:Liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:CAMK1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Neuroscience; Cardiovascular; Signal transduction\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40486696550500,"sku":"CSB-PA614509LA01HU","price":332.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_255fade2-0265-4358-9341-71317afb2d30.jpg?v=1660151600","url":"https:\/\/www.genebiosystems.com\/en-de\/products\/camk1-antibody-cat-csb-pa614509la01hu","provider":"GeneBio ","version":"1.0","type":"link"}