BMP10 Antibody - Cat. #: CSB-PA002734LA01HU

SKU: CSB-PA002734LA01HU

Size :50ug

Clone Number:

Aliases:BMP-10 antibody; Bmp10 antibody; BMP10_HUMAN antibody; Bone morphogenetic protein 10 antibody; Bone morphogenetic protein 10 preproprotein antibody; MGC126783 antibody; OTTHUMP00000159973 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O95393

Immunogen:Recombinant Human Bone morphogenetic protein 10 protein (317-424AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:BMP10

Research Areas:Cardiovascular; Signal transduction